Advanced Cell Sorting & Bioparticle Manipulation

 


Our research in Cell Sorting and Bioparticle Manipulation focuses on developing high-throughput, label-free, and quality-driven isolation platforms for clinical diagnostics, cell therapy, and reproductive medicine. The precise separation and isolation of target biological cells from heterogeneous physiological samples remain fundamental prerequisites for downstream genomic, proteomic, and phenotypic analyses. We design innovative sorting mechanisms that exploit intrinsic biomechanical, morphological, and behavioral phenotypes such as cellular deformability, membrane elasticity, surface properties, and active motility.

By integrating bioinspired boundary interactions, continuous separation geometries, and advanced physical and physiological sorting principles, our systems achieve high cellular viability, high recovery rates, and exceptional purity, while completely eliminating the need for cytotoxic chemical labeling or damaging centrifugation protocols

 

Description

Opportunities for Students

We actively welcome motivated undergraduate, masters, and Ph.D. students across biomedical engineering, mechanical engineering, biotechnology, and data science to contribute to cutting-edge projects:

  • Biomechanical & Structural Researchers:

  • Investigating and modeling the mechanical responses, structural integrity, and deformation behavior of cells under external physical forces and boundary interactions, establishing theoretical foundations for label-free sorting criteria.

  • Biomedical Engineers & Biophysicists:

  • Studying cell surface adhesion dynamics, morphological variations, and intrinsic motility behaviors across diverse biological samples (e.g., rare circulating tumor cells, stem cells, and reproductive cells) to optimize physiological separation thresholds.

  • Biotechnology & Life Sciences Specialists:

  • Evaluating post-isolation biological viability, membrane integrity, functional activity, and genomic/DNA quality, refining sample preparation protocols, and validating assay performance against gold-standard clinical workflows.

  • Instrumentation, AI & Computer Vision Specialists:

  • Developing automated high-resolution microscopy imaging pipelines, real-time single-cell tracking algorithms, automated classification models, and intelligent electro-mechanical actuation interfaces for precision automated sorting platforms.

 

References

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